It’s Day 2 at CPhI and the remaining findings of the annual expert industry report were released today during the show. As continuous processing continues to revolutionize manufacturing, Emil Ciurczak, principal at Doramax Consulting, believes that large batch production will one day be a thing of the past.
“We’ve had improved measurement systems, including light-induced fluorescent spectroscopy (LIFS), near infrared (NIR) and Raman, for years, and have used them to guarantee mixing,” noted Ciurczak, “but now there are automated systems that operate continuously that will allow us to speed up pre-pilot-scale work in design of experiments (DOE), technology transfer and the determination of the design space.” He pointed out that these systems eliminate some of the problems observed with conventional methods when moving from laboratory scale to small manufacturing scale. DOE can now be done in a matter of days with the newer systems instead of weeks or months. Such improved tools lower the costs of manufacturing and enable branded players to get more value out of their products while still under patent. According to Ciurczak, there will be less complains in the future about DOE and quality by design (QbD) costing too much or tying up equipment. Read more »