Comments on: IMS Predictions Foretell Change, Positive Change http://blog.pharmtech.com/2012/08/30/ims-predictions-foretell-change-positive-change/ The blog of Pharmaceutical Technology magazine Thu, 09 May 2013 23:30:55 -0400 http://wordpress.org/?v=2.8.4 hourly 1 By: mike http://blog.pharmtech.com/2012/08/30/ims-predictions-foretell-change-positive-change/comment-page-1/#comment-48263 mike Tue, 04 Sep 2012 17:23:14 +0000 http://blog.pharmtech.com/?p=5883#comment-48263 I see a different trend when one looks slightly earlier in the pipeline. The drop of 40% in VC funding indicates a coming hole in innovative drugs in about 5-10 years. The drop is accompanied by a focus of both VC and corporations on incremental, low risk product development focused on established pathways. I don't have data but I wouldn't be surprised in a deeper analysis of the increase in NMEs is actually less novel than expected. Look at any pathway such as anti-TNF and you'll see large numbers of barely differentiated molecules. Are these really NMEs? Of course, marginal improvements in chemical structure can sometimes bring significant advantages in efficacy, safety, or administration. It remains to be seen if this latest wave of "new" compounds will provide these kind of advantages. I see a different trend when one looks slightly earlier in the pipeline. The drop of 40% in VC funding indicates a coming hole in innovative drugs in about 5-10 years. The drop is accompanied by a focus of both VC and corporations on incremental, low risk product development focused on established pathways.

I don’t have data but I wouldn’t be surprised in a deeper analysis of the increase in NMEs is actually less novel than expected. Look at any pathway such as anti-TNF and you’ll see large numbers of barely differentiated molecules. Are these really NMEs?

Of course, marginal improvements in chemical structure can sometimes bring significant advantages in efficacy, safety, or administration. It remains to be seen if this latest wave of “new” compounds will provide these kind of advantages.

]]> By: Rajesh http://blog.pharmtech.com/2012/08/30/ims-predictions-foretell-change-positive-change/comment-page-1/#comment-48188 Rajesh Fri, 31 Aug 2012 03:59:27 +0000 http://blog.pharmtech.com/?p=5883#comment-48188 We need to be careful in making up our mind based only on values. US has less than 5% of Global population which at some point in time few years back accounted for more than half of Global Consumption of medicines. What does this actually mean? It makes little sense to have comparisons without bringing in price parity. Hope some day this would be factored while presenting data. We need to be careful in making up our mind based only on values. US has less than 5% of Global population which at some point in time few years back accounted for more than half of Global Consumption of medicines. What does this actually mean? It makes little sense to have comparisons without bringing in price parity. Hope some day this would be factored while presenting data.

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